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Mutations within the coding region end in structurally irregular proteins that have a loss or gain of operate or a novel property that causes disease. Whereas neonates have reduced clearance of many drugs, chil- dren 2–6 years of age have greater weight-normalized clearance than adults for many drugs. The stage of disease determines the criteria for partner noti cation: a) for primary syphilis, all sexual contacts through the three months previous onset of symptoms; b) for secondary syphilis, contacts during the previous 6 months; c) for early latent syphilis, those of the preceding yr, if time of primary and secondary lesions cannot be established; d) for late and late latent syphilis, marital companions, and children of contaminated moms; and e) for congenital syphilis, all members of the instant household erectile dysfunction free treatment levitra_jelly 20mg for sale.